What is the (2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-ethoxyphenyl)(hydroxy)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol?

(2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-ethoxyphenyl)(hydroxy)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is , while it's Molecular Formula is C 21 H 25 ClO 7 . (1S)-1,5-anhydro-1-C-[4-Chloro-3-[(4-ethoxyphenyl)hydroxymethyl]phenyl]-D-glucitol is an impurity of the drug Dapagliflozin (D185370), a sodium-glucose transporter 2 inhibitor.

What is the CAS number for (2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-ethoxyphenyl)(hydroxy)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol?

The CAS number of (2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-ethoxyphenyl)(hydroxy)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is 1204222-85-4.

What is (2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-ethoxyphenyl)(hydroxy)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (1204222-85-4) used for?

(2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-ethoxyphenyl)(hydroxy)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is a complex organic compound with a unique molecular structure. It is characterized by its stereochemistry, with five chiral centers and a hydroxymethyl group attached to a tetrahydro-2H-pyran ring. (2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-ethoxyphenyl)(hydroxy)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is an impurity found in the drug Dapagliflozin, which is a sodium-glucose transporter 2 (SGLT2) inhibitor used for treating type 2 diabetes.

What is the (2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-ethoxyphenyl)(hydroxy)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol?

(2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-ethoxyphenyl)(hydroxy)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is , while it's Molecular Formula is C 21 H 25 ClO 7 . (1S)-1,5-anhydro-1-C-[4-Chloro-3-[(4-ethoxyphenyl)hydroxymethyl]phenyl]-D-glucitol is an impurity of the drug Dapagliflozin (D185370), a sodium-glucose transporter 2 inhibitor.

What is the CAS number for (2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-ethoxyphenyl)(hydroxy)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol?

The CAS number of (2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-ethoxyphenyl)(hydroxy)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is 1204222-85-4.

What is (2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-ethoxyphenyl)(hydroxy)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (1204222-85-4) used for?

(2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-ethoxyphenyl)(hydroxy)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is a complex organic compound with a unique molecular structure. It is characterized by its stereochemistry, with five chiral centers and a hydroxymethyl group attached to a tetrahydro-2H-pyran ring. (2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-ethoxyphenyl)(hydroxy)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is an impurity found in the drug Dapagliflozin, which is a sodium-glucose transporter 2 (SGLT2) inhibitor used for treating type 2 diabetes.

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1204222-85-4

Product Name：Dapagliflozin Impurity
Molecular Formula：
Purity：99%
Molecular Weight：424.878

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Product Details;

CasNo： 1204222-85-4

Manufacturer supply top purity Dapagliflozin Impurity 1204222-85-4 with ISO standards

Molecular Formula:C₂₁H₂₅ClO₇
Molecular Weight:424.878
Melting Point:>79°C (dec.)
Boiling Point:651.8±55.0 °C(Predicted)
Density:1.409±0.06 g/cm3(Predicted)

1204222-85-4 Relevant articles

Synthesis of metabolites of dapagliflozin: an SGLT2 inhibitor

Bonige, Kishore Babu,Chavakula, Ramadas,Karumanchi, Kishore,Korupolu, Raghu Babu,Natarajan, Senthil Kumar,Peruri, Badarinadh Gupta

, (2020/02/21)

Abstract: Dapagliflozin is one of the gl...

1204222-85-4 Process route

: 461432-22-4
(5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)methanone

: 1204222-85-4
(2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-ethoxyphenyl)(hydroxy)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: toluene-4-sulfonic acid / methanol / 24 h / Reflux 2.1: n-butyllithium / tetrahydrofuran; toluene; hexane / 0.5 h / -80 - -75 °C / Inert atmosphere 2.2: 1 h / -80 - -75 °C / Inert atmosphere 2.3: 16 h / 20 - 30 °C / Inert atmosphere 3.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 2 h / -40 - 0 °C 4.1: sodium tetrahydroborate / methanol / 16 h / 20 - 30 °C With triethylsilane; sodium tetrahydroborate; n-butyllithium; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; toluene;

Yield

Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / methanol / 24 h / Reflux

2.1: n-butyllithium / tetrahydrofuran; toluene; hexane / 0.5 h / -80 - -75 °C / Inert atmosphere

2.2: 1 h / -80 - -75 °C / Inert atmosphere

2.3: 16 h / 20 - 30 °C / Inert atmosphere

3.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 2 h / -40 - 0 °C

4.1: sodium tetrahydroborate / methanol / 16 h / 20 - 30 °C

With triethylsilane; sodium tetrahydroborate; n-butyllithium; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; toluene;

: (2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)(ethoxyphenyl)methanone

: 1204222-85-4
(2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-ethoxyphenyl)(hydroxy)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Conditions

Conditions	Yield
With sodium tetrahydroborate; In methanol; at 20 - 30 ℃; for 16h;	85%

1204222-85-4 Upstream products

461432-25-7
(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
461432-22-4
(5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)methanone

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1204222-85-4

Product Details;

Manufacturer supply top purity Dapagliflozin Impurity 1204222-85-4 with ISO standards

1204222-85-4 Relevant articles

Synthesis of metabolites of dapagliflozin: an SGLT2 inhibitor

Bonige, Kishore Babu,Chavakula, Ramadas,Karumanchi, Kishore,Korupolu, Raghu Babu,Natarajan, Senthil Kumar,Peruri, Badarinadh Gupta

, (2020/02/21)

1204222-85-4 Process route

1204222-85-4 Upstream products

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