1620758-33-9

  • Product Name:Empagliflozin α-isomer
  • Molecular Formula:
  • Purity:99%
  • Molecular Weight:450.916
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Product Details;

CasNo: 1620758-33-9

Manufacturer supply top purity Empagliflozin α-isomer 1620758-33-9 with GMP standards

  • Molecular Formula:C23H27ClO7
  • Molecular Weight:450.916
  • Boiling Point:664.5±55.0 °C(Predicted) 
  • PKA:13.23±0.70(Predicted) 
  • Density:1.398±0.06 g/cm3(Predicted) 

1620758-33-9 Relevant articles

New Glyflozin Synthesis Method in a Continuous Reaction Process

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Paragraph 0281; 0282; 0289-0292; 0299-0301, (2021/09/07)

The present invention relates to a metho...

IMPROVED PROCESS FOR THE PREPARATION OF EMPAGLIFLOZIN AND ITS CRYSTALLINE POLYMORPH

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Page/Page column 4; 9-11, (2021/12/31)

The present invention relates to an impr...

Preparation method of SGLT-2 inhibitor and intermediate

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, (2021/05/19)

The invention discloses a preparation me...

Synthetic method of empagliflozin

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Paragraph 0029-0033, (2021/07/24)

The invention belongs to the technical f...

1620758-33-9 Process route

C<sub>51</sub>H<sub>49</sub>ClO<sub>7</sub>

C51H49ClO7

empagliflozin
864070-44-0,1620758-33-9,864070-43-9

empagliflozin

Conditions
Conditions Yield
With hydrogen; In ethanol; at 75 - 80 ℃; for 20h; under 6000.6 - 6750.68 Torr; Solvent; Inert atmosphere; Autoclave;
93.7%
(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
864070-37-1

(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

(R)-tetrahydrofuran-3-yl 4-methylbenzenesulfonate
219823-47-9

(R)-tetrahydrofuran-3-yl 4-methylbenzenesulfonate

empagliflozin
864070-44-0,1620758-33-9,864070-43-9

empagliflozin

Conditions
Conditions Yield
With caesium carbonate; In N,N-dimethyl-formamide; at 75 ℃; for 21h;
57%
With caesium carbonate; In N,N-dimethyl-formamide; at 75 ℃; for 18h;
49%
With caesium carbonate; In N,N-dimethyl-formamide; at 75 ℃; for 18h;
49%
With caesium carbonate; at 25 - 40 ℃;
With caesium carbonate; In N,N-dimethyl-formamide; at 30 - 45 ℃; for 24h;
0.55 kg

1620758-33-9 Upstream products

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