What is the (R,S)-Palonosetron Hydrochloride?

(R,S)-Palonosetron Hydrochloride is , while it's Molecular Formula is C19H25ClN2O. The (R,S)-enantiomer of Palonosetron (P165800), a potent and selective antagonist, with 5-HT3 receptor in vitro. An impurity of Palonosetron.

What is the CAS number for (R,S)-Palonosetron Hydrochloride?

The CAS number of (R,S)-Palonosetron Hydrochloride is 135755-51-0.

What is (R,S)-Palonosetron Hydrochloride (135755-51-0) used for?

(R,S)-Palonosetron Hydrochloride, also known as P165800, is a potent and selective antagonist of the 5-HT3 receptor. It is an enantiomer of Palonosetron, which is a medication used to prevent nausea and vomiting caused by certain types of chemotherapy, radiation therapy, and surgery. The compound exhibits high affinity and selectivity for the 5-HT3 receptor, making it a valuable pharmaceutical candidate for various applications.

What is the (R,S)-Palonosetron Hydrochloride?

(R,S)-Palonosetron Hydrochloride is , while it's Molecular Formula is C19H25ClN2O. The (R,S)-enantiomer of Palonosetron (P165800), a potent and selective antagonist, with 5-HT3 receptor in vitro. An impurity of Palonosetron.

What is the CAS number for (R,S)-Palonosetron Hydrochloride?

The CAS number of (R,S)-Palonosetron Hydrochloride is 135755-51-0.

What is (R,S)-Palonosetron Hydrochloride (135755-51-0) used for?

(R,S)-Palonosetron Hydrochloride, also known as P165800, is a potent and selective antagonist of the 5-HT3 receptor. It is an enantiomer of Palonosetron, which is a medication used to prevent nausea and vomiting caused by certain types of chemotherapy, radiation therapy, and surgery. The compound exhibits high affinity and selectivity for the 5-HT3 receptor, making it a valuable pharmaceutical candidate for various applications.

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135755-51-0

Product Name：(R,S)-Palonosetron HCl
Molecular Formula：C19H25ClN2O
Purity：99%
Molecular Weight：332.8676

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Product Details;

CasNo： 135755-51-0

Molecular Formula： C19H25ClN2O

Manufacturer Sells Best Quality (R,S)-Palonosetron HCl 135755-51-0 with stock

Molecular Formula:C19H25ClN2O
Molecular Weight:332.8676
Melting Point:>197°C (dec.)
PSA：23.55000
LogP:3.33430

135755-51-0 Relevant articles

A short total synthesis of palonosetron using catalytic hydrogenation

Kowalczyk, Bruce A.

, p. 1439 - 1446 (1996)

The 5-HT3 receptor antagonists (1) and (...

Hydrochloric acid palonosetron and intermediate preparation method (by machine translation)

-

, (2018/07/07)

The invention discloses hydrochloric aci...

Preparation method of high-purity palonosetron hydrochloride

-

, (2018/08/04)

The invention discloses a preparation me...

A hydrochloric acid palonosetron production method

-

Paragraph 0054-0056, (2017/08/25)

The invention belongs to the field of or...

METHOD FOR PRODUCING HYDROBENZ ISOQUINOLINE COMPOUND

-

Paragraph 0059, (2017/04/14)

PROBLEM TO BE SOLVED: To provide a novel...

135755-51-0 Process route

: 1914-65-4
tetralin-1-carboxylic acid

: 135755-51-0
palonosetron hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: N,N-dimethyl-formamide; thionyl chloride / ethyl acetate / 2.5 h / 55 °C 2.1: triethylamine / ethyl acetate / 2 h / 10 °C / Inert atmosphere 2.2: 36 h / 25 - 50 °C / Inert atmosphere 3.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 2.1 h / 10 °C / Reflux 4.1: toluene / 35 h / 10 - 25 °C / Inert atmosphere 4.2: 10 h / 20 °C With sodium tetrahydroborate; thionyl chloride; boron trifluoride diethyl etherate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; ethyl acetate; toluene;
Multi-step reaction with 4 steps 1.1: quinine / ethanol / 0.5 h / 0 - 50 °C 2.1: N,N-dimethyl-formamide; oxalyl dichloride / ethyl acetate / 1.05 h / 20 °C 2.2: 3 h / 50 °C 3.1: boron trifluoride diethyl etherate; sodium tetrahydroborate / tetrahydrofuran / 3 h / 15 - 65 °C 4.1: bis(trichloromethyl) carbonate / toluene / 3.5 h / Reflux 4.2: 4 h / Reflux 4.3: 2 h / Reflux With sodium tetrahydroborate; oxalyl dichloride; bis(trichloromethyl) carbonate; boron trifluoride diethyl etherate; quinine; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; ethyl acetate; toluene;

Yield

Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide; thionyl chloride / ethyl acetate / 2.5 h / 55 °C

2.1: triethylamine / ethyl acetate / 2 h / 10 °C / Inert atmosphere

2.2: 36 h / 25 - 50 °C / Inert atmosphere

3.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 2.1 h / 10 °C / Reflux

4.1: toluene / 35 h / 10 - 25 °C / Inert atmosphere

4.2: 10 h / 20 °C

With sodium tetrahydroborate; thionyl chloride; boron trifluoride diethyl etherate; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; ethyl acetate; toluene;

Multi-step reaction with 4 steps

1.1: quinine / ethanol / 0.5 h / 0 - 50 °C

2.1: N,N-dimethyl-formamide; oxalyl dichloride / ethyl acetate / 1.05 h / 20 °C

2.2: 3 h / 50 °C

3.1: boron trifluoride diethyl etherate; sodium tetrahydroborate / tetrahydrofuran / 3 h / 15 - 65 °C

4.1: bis(trichloromethyl) carbonate / toluene / 3.5 h / Reflux

4.2: 4 h / Reflux

4.3: 2 h / Reflux

With sodium tetrahydroborate; oxalyl dichloride; bis(trichloromethyl) carbonate; boron trifluoride diethyl etherate; quinine; N,N-dimethyl-formamide; In tetrahydrofuran; ethanol; ethyl acetate; toluene;

: 135729-55-4
(S)-2-<1-azabicyclo<2.2.2>oct-3-yl>-2,4,5,6-tetrahydro-1-oxo-1H-benzisoquinoline hydrochloride

: 135755-51-0
palonosetron hydrochloride

Conditions

Conditions	Yield
With hydrogen; palladium on activated charcoal;	57%
With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 24h; under 2585.81 Torr;	> 99 % de
With hydrogen; palladium on activated charcoal; In methanol; at 25 - 35 ℃; under 2585.81 Torr;
With hydrogen; palladium 10% on activated carbon; In propan-1-ol; at 25 - 60 ℃; under 2942.29 - 8091.3 Torr;

135755-51-0 Upstream products

135729-55-4
(S)-2-<1-azabicyclo<2.2.2>oct-3-yl>-2,4,5,6-tetrahydro-1-oxo-1H-benzisoquinoline hydrochloride
1193337-96-0
2-[(S)-1-aza-bicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one hydrochloride
81-84-5
1,8-Naphthalic anhydride
120570-05-0
(S)-3-aminoquinuclidine

135755-51-0 Downstream products

135729-60-1
palonosetron

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135755-51-0

Product Details;

Manufacturer Sells Best Quality (R,S)-Palonosetron HCl 135755-51-0 with stock

135755-51-0 Relevant articles

A short total synthesis of palonosetron using catalytic hydrogenation

Kowalczyk, Bruce A.

, p. 1439 - 1446 (1996)

Hydrochloric acid palonosetron and intermediate preparation method (by machine translation)

-

, (2018/07/07)

Preparation method of high-purity palonosetron hydrochloride

-

, (2018/08/04)

A hydrochloric acid palonosetron production method

-

Paragraph 0054-0056, (2017/08/25)

METHOD FOR PRODUCING HYDROBENZ ISOQUINOLINE COMPOUND

-

Paragraph 0059, (2017/04/14)

135755-51-0 Process route

135755-51-0 Upstream products

135755-51-0 Downstream products

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