Product Classification
- drug impurity
- drug standards
- Metaraminol bitartrate
- analytical chemistry
- standard substances
- chemical custom synthesis
- Azithromycin
- Atorvastatin
- (S)-Cinacalcet
- Ilaprazole
- Tranexamic Acid
- Duloxetine
- Octreotide
- Budesonide
- Carboprost Trometamol
- Minocycline
- Dobutamine
- Netupitant
- Axitinib
- Omadacycline
- Brivaracetam
- Metoprolol
- Indobufen
- Empagliflozin
- Dapagliflozin
- Acetylcysteine
- Hydroxychloroquine
- Tegoprazan
- Lenalidomide
- Canagliflozin
- Bromocriptine
- Rasagiline
- Bortezomib
- Diclofenac
- Bisoprolol
- Rocuronium Bromide
- Esmolol
- Bromhexine
- Probucol
- Formoterol
- Crisaborole
- Pitavastatin (3S,5S)-Isomer Calcium
- Bumetanide
- Dotinurad
- Fulvestrant
- Dotinurad
- Landiolol
Contact us
Tel：+86 17320513646
Phone：+86 17320513646
Website：https://www.moxinchem.com
Email： mike@molcoo.com
Address：Room 005, 15th Floor, Building D2, Phase III, Software New Town, No. 8 Huacheng Avenue, East Lake High-tech Development Zone, Wuhan, Hubei Province, China
1030825-20-7
- Product Name：Canagliflozin Impurity
- Molecular Formula：C18H14BrFS
- Purity：99%
- Molecular Weight：361.278
Product Details;
CasNo： 1030825-20-7
Molecular Formula： C18H14BrFS
Manufacturer supply high quality Canagliflozin Impurity 1030825-20-7 with ISO standards
- Molecular Formula:C18H14BrFS
- Molecular Weight:361.278
- Melting Point:103 °C
- Boiling Point:438.3±40.0 °C(Predicted)
- PSA：28.24000
- Density:1.388
- LogP:6.21590
2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene(Cas 1030825-20-7) Usage
InChI:InChI=1S/C18H14BrFS/c1-12-2-5-15(19)10-14(12)11-17-8-9-18(21-17)13-3-6-16(20)7-4-13/h2-10H,11H2,1H3
1030825-20-7 Relevant articles
METHOD FOR PRODUCING 5-BROMO-2-ALKYLBENZOIC ACID
-
Paragraph 0068; 0075-0078, (2021/09/03)
PROBLEM TO BE SOLVED: To provide a metho...
Preparation method of 2-(4-fluorophenyl)-5-[(5-bromo-2-methylphenyl)methyl]thiophene
-
Paragraph 0033; 0039-0040; 0042; 0046-0048; 0052-0054; 0058, (2020/06/17)
The invention relates to the technical f...
Preparation method of intermediate
-
Paragraph 0025; 0029, (2020/06/29)
The invention discloses a preparation me...
Preparation method for canagliflozin intermediate
-
, (2020/03/09)
The invention relates to a preparation m...
1030825-20-7 Process route
-
-
2-(4-fluorophenyl)-5-((5-amino-2-methylphenyl)methyl)thiophene
-
![3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl bromide](/upload/2024/12/3ff8c73b-4a5e-4a17-a0d4-ef0b95331a24.png)
-
1030825-20-7
3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl bromide
| Conditions | Yield |
|---|---|
|
2-(4-fluorophenyl)-5-((5-amino-2-methylphenyl)methyl)thiophene;
With
nitrous acid isobutyl ester; copper(I) bromide;
In
acetone;
for 1h;
Cooling with ice;
With
hydrogen bromide;
In
water;
at 90 ℃;
for 1h;
Temperature;
|
84% |
|
2-(4-fluorophenyl)-5-((5-amino-2-methylphenyl)methyl)thiophene;
With
nitrous acid isobutyl ester; copper(I) bromide;
In
acetone;
at -5 ℃;
for 1h;
With
hydrogen bromide;
In
water;
at 80 ℃;
for 2h;
Temperature;
|
82% |
-
-
58861-48-6
2-(4-fluorophenyl)thiophene
-
-
79669-49-1
5-bromo-2-methylbenzoic acid
-
-
1030825-20-7
3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl bromide
| Conditions | Yield |
|---|---|
|
5-bromo-2-methylbenzoic acid;
With
thionyl chloride;
In
dichloromethane; N,N-dimethyl-formamide;
at 50 ℃;
for 1h;
With
titanium tetrachloride;
In
dichloromethane; N,N-dimethyl-formamide;
at 0 - 5 ℃;
for 0.416667h;
2-(4-fluorophenyl)thiophene;
In
dichloromethane; N,N-dimethyl-formamide;
at 5 ℃;
for 17h;
|
85.9% |
|
Multi-step reaction with 2 steps
1.1: thionyl chloride / N,N-dimethyl-formamide; dichloromethane / 0 - 35 °C
1.2: 0 - 35 °C
2.1: aluminum (III) chloride / tetrahydrofuran / 0.5 h / 0 - 5 °C
2.2: Reflux
With
aluminum (III) chloride; thionyl chloride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
|
1030825-20-7 Upstream products
-
1132832-75-7
(5-bromo-2-methylphenyl)[5-(p-fluorophenyl)thiophene-2-yl]methanone
-
460-00-4
1-Bromo-4-fluorobenzene
-
58861-48-6
2-(4-fluorophenyl)thiophene
-
21900-41-4
5-bromo-2-methylbenzoyl?chloride
1030825-20-7 Downstream products
-
1030825-21-8
methyl 1-C-(3-{[5-(4-fluorophenyl)-2-thienyl]methyl}-4-methyl-phenyl)-D-glucopyranoside
-
898566-17-1
(2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene)
-
1413373-77-9
(1R,4R,5S,6R)-4,5,6-tris(benzyloxy)-3-(benzyloxymethyl)-1-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)cyclohex-2-enol
-
1432591-84-8
2,4-di-O-tert-butyldiphenylsilyl-1-C-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-β-D-glucopyranoside
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